Sitagliptin, Uses, Side Effects and Type 2 Diabetes


Sitagliptin phosphate with brand leader JANUVIA is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) Enzyme. It is being used for the indication of conditions like type 2 diabetes mellitus. It contains an empirical formula of C16H15F6N5O.H3P04.H2O. Sitagliptin is combined with metformin to control glucose levels in our bodies.

Sitagliptin actually increases incretins. Incretin’s main function is to control blood sugar and also it increases insulin in our body when we take meals. On the other side, it also decreases the sugar your liver makes after the meal. Therefore, always check your glucose level before meals. There is a sugar level test called glycated hemoglobin (A1C) that shows how much sugar (glucose) exists in your body in the past 2 months.


Blood Sugar Levels of Diabetes

Age 18+Levels
Before meal70-130 is normal
After Meal Less than 180 is normal
In FastingLess than 100 is normal
Bedtime100-140 is normal
Type 1 Diabetes126-200
Type 2 DiabetesMore than 200

How to use Sitagliptin?

It is an oral tablet, taken before a meal with water.

It is being used for the indicated treatment of high blood sugar levels, which causes type 2 diabetes.

The dosage of this medicine is 1 tablet daily, depends on your sugar level. Therefore consult your physician before taking sitagliptin.

Not recommended for patients having type 1 diabetes.

Symptoms of Type 2 Diabetes

It will increase your thirst and hunger

It will increase urination

You will feel tired and bored

You will face blurred vision

Sores are not healing properly

You will find a weight loss

If you have already type 1 diabetes, better to check your sugar level often, because in type 2 diabetes

Difference between Type 1 Diabetes VS Type 2 Diabetes

Type 1 DiabetesType 2 Diabetes
Main cause in type 1 diabetes is that,Main cause in type 2 diabetes is that, your body cannot make enough insulin or it is not working properly
Your body’s immune system is not working properly or it not make enough insulin
The symptoms in type 1 diabetes appear quicklyOn the other hand in type 2 diabetes the symptoms appear slowly
Type 1 diabetes is more or less manageable. Taking glucophage can control type 1 diabetesWhile type 2 diabetes is in severe condition, you need to take sitagliptin along with diet and exercise.
The level of Glucose level is not too highThe level of glucose level in type 2 diabetes is too high
Children and adults often got type 1 diabetesAll ages having type 2 diabetes, but there are more chances in age more than 40

Side Effects of Sitagliptin

Severe side effects of sitagliptin include hypoglycemia, pancreatitis, and hypoglycemia upper respiratory tract infection, etc.

Overdose side effects of sitagliptin cause coma, seizures, confusion, tachycardia, drowsiness, dizziness, sweating, headache, weakness, and tremor, etc.

Common side effects of Sitagliptin include nausea, headache, upset stomach, drowsiness, sore throat, irritating nose, and vomiting, etc.