Sita-Met is produced by CCL Pharmaceuticals. It contains Sitagliptin plus Metformin HCL. It is being used for the treatment of type 2 diabetes mellitus. It slowdowns inactivation of incretin hormones and these hormones include glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide (GIP, which is released by the intestine. The increase in these hormones is rapidly inactivated by the enzyme DPP-4.
Excessive insulin is being released from the pancreatic beta cells. Sitagliptin actually increases insulin release and reduces glucagon levels.
While Metformin HCL lowers both basal and postprandial plasma glucose. It also decreases hepatic glucose production and reduces intestinal absorption of glucose.
The main function of Metformin is to control high blood sugar. High blood sugar causes kidney damage; nerve problems and it also causes blindness. High blood sugar level also causes sexual weakness. Therefore it is essential to use Metformin to prevent such kinds of diseases. Metformin actually decreases the sugar level in the liver.
Indications, signs, and symptoms of type 2 diabetes
Sita-Met is being used for only type 2 diabetes mellitus; therefore do not use it for type 1 diabetes mellitus. In type 2 diabetes, the pancreas and cells do not work properly and your body is producing more insulin than it requires. This glucose builds in the bloodstream and starts creating problems.
Type 2 diabetes risk factors
Many factors are involved in type 2 diabetes, such as your age, family, ethnicity, and a number of diseases linked with glucose and blood. You have more chances of diabetes if your age is more than 45 years or if you have family members with diabetes. Some diseases also cause diabetes such as heart and blood vessel disease, high triglycerides, high blood pressure, depression, obesity, etc.
Symptoms
Being very thirsty
Blurry vision
Numbness in your hands and feet
Fatigue
Yeast infection
Feeling hungry
Weight loss
Dosage and Administration
The initial dosage started from 50mg Sitagliptin plus 500mg Metformin once daily. The dosage can be increased from 50/850mg to 50/1000mg by monitoring the patient’s response. Better to see the response of the patient and tolerability while exceeding the maximum dosage.
Side Effects of Sita-Met
Sitagliptin: Side effects of Sitagliptin include pancreatitis, fever, peeling, redness of skin, hypoglycemia, nausea, diarrhea, fatigue, etc. Acute overdosage of Sitagliptin can cause seizures, drowsiness, confusion, sweating, tremor, coma, headache, etc.
Metformin HCL: Some common side effects of Metformin include nausea, vomiting, headache, skin rashes, weight loss, upset stomach, etc. While the severe and irreversible adverse effects include pneumonitis, malabsorption of folic acid, anemia and vasculitis, etc.
It has clinically observed that less than 6% of patients are reported diarrhea, headache, and respiratory tract infection. Hypoglycemia was also reported in these patients.
Warnings and precautions
Before using Sita-Met tell your doctor if you are allergic to Sitagliptin or Metformin HCL. You should also tell your doctor about your medical history so that the doctor can treat you accordingly.
Do not use Sita-Met if you have severe asthma, blood cancer, high blood pressure, liver and kidney disease, and vitamin b12 deficiency.
Secondly, do not take Sita-Met with alcohol and other benzodiazepine medicines, such as Valium and Xanax, etc.
Sita-Met 50/500mg
| SITA-MET 50/500MG | Sitagliptin + Metformin |
|---|---|
| Compositions | Each film coated tablet contains |
| Sitagliptin Phosphate Monohydrate 50mg | |
| Metformin HCL BP 500mg | |
| Symptoms and Indications | Diabetes, Being very thirsty, Blurry vision, Weight Loss, Type 2 diabetes, Numbness in hands, High Sugar Level |
| Dosage | According to the prescription |
| Company | CCL |
| Packing | 14 Tablets |
| Per tablet price | Rs 29.4 |
Sita-Met 50/850mg
| SITA-MET 50/1000MG | Sitagliptin + Metformin |
|---|---|
| Compositions | Each film coated tablet contains |
| Sitagliptin Phosphate Monohydrate 50mg | |
| Metformin HCL BP 850mg | |
| Symptoms and Indications | Diabetes, Being very thirsty, Blurry vision, Weight Loss, Type 2 diabetes, Numbness in hands, High Sugar Level |
| Dosage | According to the prescription |
| Company | CCL |
| Packing | 14 Tablets |
| Per tablet price | Rs 29.2 |
Sita-Met 50/1000mg
| SITA-MET 50/850MG | Sitagliptin + Metformin |
|---|---|
| Compositions | Each film coated tablet contains |
| Sitagliptin Phosphate Monohydrate 50mg | |
| Metformin HCL BP 1000mg | |
| Symptoms and Indications | Diabetes, Being very thirsty, Blurry vision, Weight Loss, Type 2 diabetes, Numbness in hands, High Sugar Level |
| Dosage | According to the prescription |
| Company | CCL |
| Packing | 14 Tablets |
| Per tablet price | Rs 32 |