Lasix is produced by Sanofi-Aventis, it contains furosemide. It is being used for the indication and treatment of cardiac failure, chronic renal failure, nephrotic syndrome, hypertension, and forced diuresis. Furosemide actually reduces extra fluids in our body, which causes heart failure. It also reduces blood pressure and prevents strokes. After using furosemide it can cause urination, through which you can get rid of extra salty water.
Indications
Fluid retention associated with chronic congestive failure
Acute congestive cardiac failure
Chronic renal failure
Acute renal failure, including that due to pregnancy or burns
Nephrotic syndrome if diuretic treatment is required
Liver disease if necessary to supplement treatment with aldosterone antagonists
To treat hypertension
Also being used to support forced diuresis
Dosage
Initially, the dosage should be the lowest to achieve the desired effect but it can be increased after medical examination. The composition of furosemide is in three forms, 20mg and 40mg tablets for oral use while 2ml injection is for intravenously. Lasix should be taken on an empty stomach and swallowed without chewing with some warm water.
| Disease | Dose |
| Hepatic impairment, fluid retention associated with liver disease | 20mg to 80mg with 24 hours |
| Renal Impairment, fluid retention associated with chronic renal failure | 40mg-80mg with 24 hours |
| Renal impairment, maintenance of fluid excretion in acute renal failure | 50mg to 100mg/hours and should be intravenous infusion |
| Renal impairment, fluid retention associated with nephrotic syndrome | 40mg to 80mg with 24 hours |
| Fluid Retention associated with chronic congestive cardiac failure | 20mg to 80mg within 24 hours |
| Fluid retention associated with acute congestion cardiac failure | 20mg to 40mg intravenously within 24 hours |
| Hypertension | 20mg to 40mg within 24 hours |
| Support of forced dieresis in poisoning | 20-40mg intravenously |
Note: Intramuscular injection: Do not use furosemide intramuscularly. Intramuscular injection is not suitable in many cases.
For adults, the maximum dosage within 24 hours of furosemide is 1500mg.
On the other side to treat children you need to administer furosemide in relation to body weight. Oral administration for children is 2mg/kg body weight. The maximum dose within 24 hours should be less than 40mg.
Contraindications
Do not use furosemide in the following conditions
Patients who are hypersensitivity to furosemide
Patients who are allergic to sulphonamide antibiotics or sulfonylureas
Patients with hypovolaemia
Patients with dehydration
Patients with anuric renal failure
Patients with severe hyponatremia
Patients with pre-comatose and comatose states associated with hepatic encephalopathy
In breastfeeding women
In patients with latent or manifest diabetes mellitus
In patients with gout
Side Effects of Lasix Furosemide
Following CIOMS frequency rating is used
| Very common | ≥10% |
| Common | ≥1 and <10% |
| Uncommon | ≥1 0.1 and <1% |
| Rare | ≥1 o.01 and < 0.1% |
| Very rare | <0.01% |
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Metabolism and Nutrition disorders
Very common: Electrolyte disturbances include dehydration, while in elder patients it can cause blood creatinine and triglyceride increased
Common: Hypochloremia, increased blood cholesterol, blood uric acid increased, hyponatremia, and attacks of gout
Uncommon: Glucose tolerance impaired
Not known: Blood urea increased, metabolic alkalosis, hypocalcemia
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Vascular disorders
Very common: Hypotension
Rare: Vasculitis
Not known: Thrombosis
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Renal and Urinary Disorders
Common: Urine volume increased
Rare: Tubulointerstitial nephritis
Not known: Urine sodium increased, urine retention and renal failure
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Gastrointestinal Disorders
Uncommon: Nausea and vertigo
Rare: Vomiting and diarrhea
Very rare: pancreatitis acute
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Hepato-biliary Disorders
Very rare: Cholestasis and transaminases increased
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Ear and Labyrinth Disorders
Uncommon: Hearing disorders, deafness
Rare: Tinnitus
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Skin and Subcutaneous Tissue Disorders
Uncommon: Pruritus, rashes, pemphigoid, purpura, and dermatitis
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Immune System Disorders
Rare: Anaphylactic reactions occur
Not known: Exacerbation and activation of systemic lupus erythematosus
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Nervous System Disorder
Rare: paraesthesia
Common: Hepatic Encephalopathy in patients
Not known: Dizziness, fainting, or headache
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Blood and the Lymphatic System Disorder
Common: Haemoconcentration
Uncommon: Thrombocytopenia
Rare: Leucopenia and eosinophilia
Very rare: Aplastic anemia
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Musculoskeletal and Connective Tissue Disorders
Not Known: Cases of rhabdomyolysis have been reported
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Congenital and Familial Disorder
Not known: Increased risk of persistence of patent ductus arterosus
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General Disorders and Administration Site Conditions
Not known: Intramuscular injection such as pain
Rare: Fever
Pregnancy and Lactation
It actually crosses the placental barrier; therefore do not use furosemide in pregnancy. Consult your physician before taking Lasix in pregnancy.
Lactation: Furosemide passes into breast milk, therefore do not breast-feed while taking furosemide.
Lasix 20mg Tablets
Lasix 20mg Tablets Furosemide
Composition Each tablet contains Furosemide USP 20mg
Symptoms and Indications Cardiac Failure, Chronic Renal Failure, Nephritic Syndrome, Hypertension
Dose See dosage section
Company Sanofi-Aventis
Per tablet price Rs 1.55
Lasix 40mg Tablets
Lasix 40mg Tablets Furosemide
Composition Each tablet contains Furosemide USP 40mg
Symptoms and Indications Cardiac Failure, Chronic Renal Failure, Nephritic Syndrome, Hypertension
Dose See dosage section
Company Sanofi-Aventis
Per tablet price Rs 2.6
Lasix Injection
Lasix 2ml Injection Furosemide
Composition Each 2ml contains Furosemide USP 20mg
Symptoms and Indications Cardiac Failure, Chronic Renal Failure, Nephritic Syndrome, Hypertension
Dose See dosage section
Company Sanofi-Aventis
Per vial price Rs 7.94