Lasix 20/40mg, Furosemide Uses and Side Effects

Lasix is produced by Sanofi-Aventis, it contains furosemide. It is being used for the indication and treatment of cardiac failure, chronic renal failure, nephrotic syndrome, hypertension, and forced diuresis. Furosemide actually reduces extra fluids in our body, which causes heart failure. It also reduces blood pressure and prevents strokes. After using furosemide it can cause urination, through which you can get rid of extra salty water. 

Indications

Fluid retention associated with chronic congestive failure

Acute congestive cardiac failure

Chronic renal failure

Acute renal failure, including that due to pregnancy or burns

Nephrotic syndrome if diuretic treatment is required

Liver disease if necessary to supplement treatment with aldosterone antagonists

To treat hypertension

Also being used to support forced diuresis

Dosage

Initially, the dosage should be the lowest to achieve the desired effect but it can be increased after medical examination. The composition of furosemide is in three forms, 20mg and 40mg tablets for oral use while 2ml injection is for intravenously. Lasix should be taken on an empty stomach and swallowed without chewing with some warm water.

Disease Dose
Hepatic impairment, fluid retention associated with liver disease 20mg to 80mg with 24 hours
Renal Impairment, fluid retention associated with chronic renal failure 40mg-80mg with 24 hours
Renal impairment, maintenance of fluid excretion in acute renal failure 50mg to 100mg/hours and should be intravenous infusion
Renal impairment, fluid retention associated with nephrotic syndrome 40mg to 80mg with 24 hours
Fluid Retention associated with chronic congestive cardiac failure 20mg to 80mg within 24 hours
Fluid retention associated with acute congestion cardiac failure 20mg to 40mg intravenously within 24 hours
Hypertension 20mg to 40mg within 24 hours
Support of forced dieresis in poisoning 20-40mg intravenously

Note: Intramuscular injection: Do not use furosemide intramuscularly. Intramuscular injection is not suitable in many cases.

For adults, the maximum dosage within 24 hours of furosemide is 1500mg.

On the other side to treat children you need to administer furosemide in relation to body weight. Oral administration for children is 2mg/kg body weight. The maximum dose within 24 hours should be less than 40mg.

Contraindications

Do not use furosemide in the following conditions

Patients who are hypersensitivity to furosemide

Patients who are allergic to sulphonamide antibiotics or sulfonylureas

Patients with hypovolaemia

Patients with dehydration

Patients with anuric renal failure

Patients with severe hyponatremia

Patients with pre-comatose and comatose states associated with hepatic encephalopathy

In breastfeeding women

In patients with latent or manifest diabetes mellitus

In patients with gout

Side Effects of Lasix Furosemide

Following CIOMS frequency rating is used

Very common ≥10%
Common ≥1 and <10%
Uncommon ≥1 0.1 and <1%
Rare ≥1 o.01 and < 0.1%
Very rare <0.01%

 

  • Metabolism and Nutrition disorders

Very common: Electrolyte disturbances include dehydration, while in elder patients it can cause blood creatinine and triglyceride increased

Common: Hypochloremia, increased blood cholesterol, blood uric acid increased, hyponatremia, and attacks of gout

Uncommon: Glucose tolerance impaired

Not known: Blood urea increased, metabolic alkalosis, hypocalcemia

  • Vascular disorders

Very common: Hypotension

Rare: Vasculitis

Not known: Thrombosis

  • Renal and Urinary Disorders

Common: Urine volume increased

Rare: Tubulointerstitial nephritis

Not known: Urine sodium increased, urine retention and renal failure

  • Gastrointestinal Disorders

Uncommon: Nausea and vertigo

Rare: Vomiting and diarrhea

Very rare: pancreatitis acute

  • Hepato-biliary Disorders

Very rare: Cholestasis and transaminases increased

  • Ear and Labyrinth Disorders

Uncommon: Hearing disorders, deafness

Rare: Tinnitus

  • Skin and Subcutaneous Tissue Disorders

Uncommon: Pruritus, rashes, pemphigoid, purpura, and dermatitis

  • Immune System Disorders

Rare: Anaphylactic reactions occur

Not known: Exacerbation and activation of systemic lupus erythematosus

  • Nervous System Disorder

Rare: paraesthesia

Common: Hepatic Encephalopathy in patients

Not known: Dizziness, fainting, or headache

  • Blood and the Lymphatic System Disorder

Common: Haemoconcentration

Uncommon: Thrombocytopenia

Rare: Leucopenia and eosinophilia

Very rare: Aplastic anemia

  • Musculoskeletal and Connective Tissue Disorders

Not Known: Cases of rhabdomyolysis have been reported

  • Congenital and Familial Disorder

Not known: Increased risk of persistence of patent ductus arterosus

  • General Disorders and Administration Site Conditions

Not known: Intramuscular injection such as pain

Rare: Fever

Pregnancy and Lactation

It actually crosses the placental barrier; therefore do not use furosemide in pregnancy. Consult your physician before taking Lasix in pregnancy.

Lactation: Furosemide passes into breast milk, therefore do not breast-feed while taking furosemide.

Lasix 20mg Tablets

Lasix 20mg Tablets

Lasix 20mg TabletsFurosemide
CompositionEach tablet contains Furosemide USP 20mg
Symptoms and IndicationsCardiac Failure, Chronic Renal Failure, Nephritic Syndrome, Hypertension
DoseSee dosage section
CompanySanofi-Aventis
Per tablet priceRs 1.55

Lasix 40mg Tablets

Lasix 40mg Tablets

Lasix 40mg TabletsFurosemide
CompositionEach tablet contains Furosemide USP 40mg
Symptoms and IndicationsCardiac Failure, Chronic Renal Failure, Nephritic Syndrome, Hypertension
DoseSee dosage section
CompanySanofi-Aventis
Per tablet priceRs 2.6

Lasix Injection

Lasix 2ml Injection

Lasix 2ml InjectionFurosemide
CompositionEach 2ml contains Furosemide USP 20mg
Symptoms and IndicationsCardiac Failure, Chronic Renal Failure, Nephritic Syndrome, Hypertension
DoseSee dosage section
CompanySanofi-Aventis
Per vial priceRs 7.94