Gravinate Uses, Side Effect and in Pregnancy

Gravinate for Vomiting

Gravinate is produced by Searle which contains dimenhydrinate. It is being used for the prevention and relief of motion sickness and treatment of vertigo, nausea, or vomiting associated with: electroshock therapy, anesthesia, and surgery labyrinthine disturbances, radiation sickness, and postfenestration syndrome.


It is well absorbed from the gastrointestinal tract. Concurrent ingestion of food may delay the rate, but not the extent of its absorption and action. It is metabolized in the liver. It has high serum protein binding. The onset of action is within ½ to 1 hour.

Gravinate in Pregnancy and lactation

It should not be used during the first trimester of pregnancy and during breastfeeding. It may inhibit lactation due to its anticholinergic activity. Excreted amounts in breast milk may cause increased excitability, irritability, and sensitization in the breast fed infant.

Gravinate Side Effects

Signs and symptoms of hypersensitivity: skin rash, stomach upset and pain, weakness, drowsiness, tiredness and blurred vision, etc. Prolonged use of dimenhydrinate may decrease or inhibit salivary flow and lead to the development of caries, periodontal disease, oral candidiasis, and discomfort.

Parodoxical reaction may occur in children (hyperexacitability, tendency toward convulsions) and elderly patients (dizziness, confusion, hypotension, drowsiness, dryness of mouth, and urinary retention, especially in males.


Hypersensitivity to the active ingredient, epilepsy, infants, and children under 5 years of age due to increased susceptibility to anticholinergic agents and their effects.


Patients should be warned to inform physicians of use and report promptly any occurring gastrointestinal disturbances during administration. It should not be administered to children under 5 and patients in advanced age.

Be careful while driving and operating machinery. This preparation decreases attention and slows down reflexes and psychomotor reactions. Driving and operation of machinery should be avoided during therapy.


Manifestation of anticholinergic effects, which are more frequent in children (dryness of mouth, nose, and throat, difficulty breathing, redness of the face, severe drowsiness, tiredness, and weakness).

Gravinate Syrup for Children

Gravinate Syrup

Gravinate Syrup

Gravinate SyrupDimenhydrinate
Compositions Each 4ml contains
Dimenhydrinate bp 12.5mg
Symptoms Vomiting, Motion Sickness, Vertigo,
Dose (2-6 years)(4-8ml) 2 to 3 times a day
Dose (6-12 years)(8-18ml) 2-3 times a day
Dose (below 2 years)Only on advice of physician
Flavour Cherry flavoured
Retail Price Rs 40

Gravinate Tablet and Injection for Adults

Gravinate Tablet

Gravinate 50mg Tablet

Gravinate 50mg TabletDimenhydrinate
Compositions Each tablet contains
Dimenhydrinate BP 50mg
Symptoms Vomiting, Motion Sickness, Vertigo
Dose (6-8 year)½ tablet two times a day
Dose (8-12 years)½ tablet two times a day
Dose (12-18 years)1 tablet two times a day
Dose (Above 18 years)1 tablet three times a day
Per Tablet PriceRs 1.1

Gravinate Injection

Gravnate 50mg Injection

Gravinate InjectionDimenhydrinate
Compositions Each ml contains, Dimenhydrinate BP 50mg
Symptoms Vomiting, Motion Sickness, Vertigo
Dose (Above 18years) 1 injection two times a day
(IM/IV )Note: only on advice of physician
Per Ampoule priceRs 10.12